TABLE 2. Phenotypic PCOS-like Traits Found in Fetal, Infant, Adolescent and Adult Early Gestation-Exposed PA Female Rhesus Monkeys.

Developmental stage	Reproductive and endocrine PCOS-like traits	Metabolic PCOS-like traits
Fetus	LH excess1	??
Infant	Androgen excess1	Relative hypersecretion of insulin2
	LH excess1	Increased body weight2
Adolescent	Increased intermittent menstrual cycles3	Increased body weight at menarche3
	Luteal phase defects3
Adult	Ovarian hyperandrogenism4	Insulin resistance4,5
	Intermittent/absent ovulatory menstrual cycles4,6	Beta-cell defect5
	Polycystic ovaries6	Hyperlipidemia7
	LH excess and reduced estradiol/progesterone negative feedback4	Abdominal adiposity8
	Menstrual cycles normalized by insulin sensitizer treatment7	Type 2 diabetes9
	Diminished oocyte quality10
	Adrenal hyperandrogenism11

¹Abbott et al., 2008a;

²Abbott et al., 2007;

³Goy and Robinson, 1982;

⁴Abbott et al., 2005;

⁵Eisner et al., 2000;

⁶Abbott et al., 1997;

⁷Zhou et al, 2007;

⁸Eisner et al., 2003;

⁹Dumesic et al., 2005;

¹⁰Dumesic et al., 2002;

¹¹Zhou et al., 2005