Figure 4.

A comparison of parasite fitness under strategies of rationing drugs to treat 50% of cases vs. two first-line ACTs. This figure assumes that baseline drug pressure is 40% and that the biological cost is 10%. The waiting time to clinical malaria (i.e. any fever) in those with infection (x-axis) and the proportion of new infections that present with clinical symptoms (y-axis) span the relevant values for malaria. When the profile for clinical malaria resembled low-transmission settings, the benefits of MFTs were slightly lower than treating half as many patients. When the profile resembled high-transmission settings, MFTs did slightly better than rationing drugs. The colors shade in different categorical descriptions of the ratio. For most values, the ratio is within 5% of 1 (light gray).