Table 2.
Synergistic Interaction Between IL23R and IL17A, and IL23R and IL17RA
| a) IL23R and IL17A | |||||||
|---|---|---|---|---|---|---|---|
| Interaction between IL23R risk haplotypes and IL17A risk haplotype in non-Jewish subjects. | |||||||
| Presence of IL23R Block 2 H1 or IL23R Block 3 H1 |
Presence of IL17A H2 |
CD | Control | Odds Ratio |
95% Confidence Interval |
Mantel- Haenszel P value |
Interaction P value |
| No | No | 90 | 52 | 1 | 0.0017 | 0.047 | |
| No | Yes | 52 | 30 | 1.0 | 0.6-1.8 | ||
| Yes | No | 166 | 84 | 1.1 | 0.7-1.8 | ||
| Yes | Yes | 133 | 32 | 2.4 | 1.4-4.0 | ||
| b) IL23R and IL17RA | |||||||
|---|---|---|---|---|---|---|---|
| Interaction between IL23R risk haplotypes and IL17RA risk haplotype in all subjects. | |||||||
| Presence of IL23R Block 2 H1 or IL23R Block 3 H1 |
Presence of IL17RA H4 |
CD | Control | Odds Ratio |
95% Confidence Interval |
Mantel- Haenszel P value |
Interaction P value |
| No | No | 175 | 78 | 1 | 0.0003 | 0.036 | |
| No | Yes | 65 | 27 | 1.1 | 0.6-1.8 | ||
| Yes | No | 370 | 126 | 1.3 | 0.9-1.8 | ||
| Yes | Yes | 138 | 20 | 3.0 | 1.8-5.2 | ||
| c) IL23R and IL12RB2 | |||||||
|---|---|---|---|---|---|---|---|
| Interaction between IL23R risk haplotypes and IL12RB risk haplotype in all subjects. | |||||||
| IL12RB2 Haplotype 4 |
Presence of IL23R Block 2 H2 |
CD | Control | OR | 95% Confidence Interval |
Mantel- Haenszel P value |
Interaction P value |
| No | No | 294 | 55 | 1 | 0.001 | ||
| No | Yes | 329 | 132 | 0.47 | 0.33 - 0.66 | ||
| Yes | No | 45 | 32 | 0.26 | 0.15 - 0.45 | <0.0001 | |
| Yes | Yes | 76 | 29 | 0.49 | 0.29 - 0.82 | ||