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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Curr Opin Cell Biol. 2010 Mar 29;22(3):357–364. doi: 10.1016/j.ceb.2010.03.003

Figure 2.

Figure 2

Long non-coding RNA-mediated transcription regulation. A. Transcription activation by lncRNA. In this example, Evf-2 is transcribed from an ultraconserved enhancer and forms a stable complex with Dlx-2, which in turn activates Dlx-2 as a transcriptional enhancer. B. Transcription suppression by lncRNA. Top: in response to DNA damage, lncRNAs are transcribed from the 5’-upstream region of the CCND1 gene and recruit the RNA-binding protein TLS to modulate CBP and p300 to inhibit CCND1 transcription. Bottom: lncRNA transcribed from the upstream of the minor promoter of DHFR gene competes with transcription factors to inhibit the major promoter transcription in quiescent cells.

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