Skip to main content
. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Curr Opin Cell Biol. 2010 Mar 29;22(3):357–364. doi: 10.1016/j.ceb.2010.03.003

Figure 3.

Figure 3

Long non-coding RNAs in nuclear subcompartments. Human NEAT1 (Menε in mouse) localizes to paraspeckles and is required for paraspeckle structural integrity. NEAT2 (MALAT1) localizes to splicing speckles but is not required for their structural integrity. See text for details. Nascent Menβ and MALAT1 transcripts can each be processed by the unusual mechanism of RNase P cleavage to generate the 5’ end of mascRNA (MALAT1-associated small cytoplasmic RNA) and the 3’ end of the mature Menβ and MALAT1 transcripts, which localize to paraspeckles and splicing speckles, respectively.

HHS Vulnerability Disclosure