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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Curr Opin Struct Biol. 2010 Apr 24;20(3):305–312. doi: 10.1016/j.sbi.2010.03.010

Figure 3.

Figure 3

NMR structure of Human Tis11D bound to RNA [33]. Each zinc finger domain independently recognizes the sequence UAUU through a combination of base-specific hydrogen bonding interactions and stacking interactions driven by aromatic side chains. The inset shows recognition of adenosine in the N-terminal finger. Three amino acids (blue), glutamate, leucine, and cysteine, come together to form an adenosine (violet) recognition pocket. The exocyclic amine hydrogen bonds with the glutamate side chain and the backbone carbonyl of the leucing. In MEX-5, the glutamate is replaced with an arginine (red), which is proposed to flip away from the adenosine and form non-specific interactions with the backbone of adjacent nucleotides [35].