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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Pharm Res. 2010 Apr 13;28(1):135–144. doi: 10.1007/s11095-010-0134-6

Fig. 2.

Fig. 2

Kinetics of influenza vaccine stability loss during drying as measured by HA activity loss. (A) HA activity of inactivated virus and (B) virus particle size as a function of drying time. (C) Correlation between HA activity and virus particle size. Coating solution contained 5 mg/ml inactivated virus and was prepared with or without 15% trehalose. In (C), the numbers next to each data point indicate drying time in minutes. HA activity is normalized relative to a control solution of inactivated virus in PBS at the beginning of the experiment. CS = coating solution, Tre = trehalose. (n=4 replicates expressed as average ± SEM).