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. Author manuscript; available in PMC: 2011 Aug 15.
Published in final edited form as: J Immunol. 2010 Jul 21;185(4):2324–2330. doi: 10.4049/jimmunol.0903052

Figure 7. Model for XBP-1 enhanced factor recruitment to the ifnb1 promoter.

Figure 7

In the presence of LPS stimulation alone, IRF-3 and CBP bind to the ifnb1 promoter (top). When macrophages undergoing ER stress (Tpg treatment) are stimulated with LPS, XBP-1, IRF-3, and CBP cooperatively bind the region 6.1kb downstream of the ifnb1 gene. Through chromatin looping, the enhancer bound IRF3 and CBP factors are delivered to the multi-molecular complex at the ifnb1 promoter, ultimately resulting in greater recruitment of transcriptional machinery.