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By challenging PTX-sensitive Gi/o-coupled MT2 receptors on rat RGCs, melatonin potentiates glycine currents via a distinct intracellular PC-PLC/PKC pathway. Mel: melatonin; GlyR: glycine receptor; PC-PLC: phosphatidylcholine-specific phospholipase C; PC: phosphatidylcholine; DAG: diacylglycerol; PKC: protein kinase C; ℗, phosphorylation.
