Table 2.
Investigated covariatea | Number tumors | Log-rank P |
Univariate P |
Multivariate P b |
---|---|---|---|---|
ER+ vs. ER- | 64/112 | 0.96 | 0.96 | 0.79 |
LN+ vs. LN- | 110/65 | 4 × 10-6 *** | 9 × 10-6 *** | 0.0002*** |
Size >20 mm vs. ≤ 20 mm | 122/49 | 0.002** | 0.002** | 0.02* |
Histological grade 3 vs. 1 and 2 | 37/26 | 0.91 | 0.91 | 0.83 |
Age <50 vs. ≥50 years | 73/103 | 0.22 | 0.23 | 0.77 |
DNA Aneuploid vs. Diploid | 106/37 | 0.001** | 0.001** | 0.005** |
DNA Aneuploid vs. Diploid ER+ | 37/11 | 0.008** | 0.02* | 0.07 |
DNA Aneuploid vs. Diploid ER- | 69/26 | 0.05* | 0.05* | 0.06 |
Recurrent 17q amplification, yes vs. no | 70/106 | 0.17 | 0.17 | 0.13 |
Recurrent amplification excluding 17q, yes vs. no | 76/100 | 0.75 | 0.75 | 0.7 |
Firestorm pattern, yes vs. no | 78/98 | 0.27 | 0.28 | 0.58 |
High FGA vs. low FGAc | 42/46 | 0.08 | 0.09 | 0.25 |
High FGA vs. low FGA ER+ tumorsc | 18/17 | 0.09 | 0.09 | 0.26 |
High FGA vs. low FGA ER- tumorsc | 24/29 | 0.37 | 0.37 | 0.55 |
a Variables with worst outcome highlighted in bold for covariates significantly associated with OS.b Multivariate analysis included LN status and stratified tumor size besides the tested covariate.c High and Low FGA defined as >75th percentile and <25th percentile of all FGA values respectively.
*: Significant at P < 0.05
**: Significant at P < 0.01
***: Significant at P < 0.001