Table 2. Gene ontology analysis for Sre1- and Stp1-dependent genes.

GO terms were assigned to C. neoformans genes based on homology to S. cerevisiae genes. P-value represents the probability that a particular GO term is enriched in the indicated microarray gene lists. The p-value cutoff was <0.05.

GO group	GO subgroup	p-value
Up in wild-type vs. sre1Δ and stp1Δ
Cellular lipid metabolism		4.5×10−9
	Sterol biosynthesis	1.7×10−12
	Fatty acid metabolism	1.5×10−3
Coenzyme metabolism		6.1×10−3
	Pantothenate metabolism	0.031
	Co-A metabolism	0.040
	Pantothenate transport	0.023
Amino acid transport		0.013
Up in wild-type vs. stp1Δ only
Ribosome biogenesis and assembly		6.7×10−6
	Ribosome bigenesis	2.0×10−5
	rRNA processing	1.6×10−4
	Ribosome export from the nucleus	0.046
S-adenosyl methionine metabolism		1.6×10−3
RNA processing		5.5×10−3
Ergosterol biosynthesis		0.014
	Isoprenoid biosynthesis	0.020
Signal transduction and during conjugation		0.016
NAD metabolism		0.034
Maintenance of actin cytoskeleton polarity		0.046
Up in wild-type vs. sre1Δ only
Amino acid catabolism		8.3×10−3
	Branched chain amino acid catabolism	1.1×10−4
Down in wild-type vs. sre1Δ and stp1Δ
Phosphoinositide-mediated signalling		1.4×10−3
Down in wild-type vs. stp1Δ only
Disaccharide biosynthesis		1.3×10−4
	Glycerolipid biosynthesis	2.5×10−4
Down in wild-type vs. sre1Δ only
Carbohydrate metabolism		2.5×10−5
Hydrogen peroxide metabolism		7.2×10−3