Table 3.
Stratified analysis by age, gender, IR exposure history, and histological type of glioma
| Dominant |
Recessive |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| XRCC1 R399Q | PARP1 A762V | MGMT F84L | LIG1 5’UTR | ERCC1 3’ UTR | APEX1 E148D | |||||||
| Variables | OR (95% CI) * | OR (95% CI) * | OR (95% CI) * | OR (95%CI) * | OR (95% CI) * | OR (95% CI) * | ||||||
| No.† | GA/AA vs GG |
No.† | TC/CC vs TT |
No.† | CT/TT vs CC |
No.† | CT/TT vs CC |
No.† | GG vs TT/GT |
No.† | TT vs CC/CT |
|
| Age (years) | ||||||||||||
| ≤45 | 142/143 | 1.47 (0.91–2.38) |
142/143 | 0.62 (0.38–1.06) |
140/143 | 0.57 (0.32–1.00) |
142/143 | 0.46 (0.27–0.80) |
142/143 |
5.88 (1.64–20.0) |
142/143 | 0.96 (0.57–1.64) |
| >45 | 231/221 | 1.39 (0.95–2.03) |
230/221 | 0.76 (0.52–1.14) |
230/220 | 0.76 (0.49–1.20) |
230/221 | 0.85 (0.55–1.29) |
230/220 | 1.08 (0.52–2.27) |
230/220 | 0.54 (0.36–0.85) |
| P for interaction | 0.86 | 0.54 | 0.44 | 0.085 | 0.016 | 0.11 | ||||||
| Gender | ||||||||||||
| Male | 214/159 | 0.94 (0.62–1.44) |
213/159 | 0.58 (0.38–0.91) |
211/159 | 0.53 (0.32–0.88) |
213/159 | 0.79 (0.50–1.24) |
214/157 | 1.92 (0.78–4.76) |
213/158 | 0.70 (0.43–1.14) |
| Female | 158/204 |
2.27 (1.45–3.57) |
158/205 | 0.86 (0.55–1.35) |
156/203 | 0.86 (0.53–1.40) |
158/205 | 0.56 (0.34–0.92) |
156/204 | 1.79 (0.76–4.15) |
156/204 | 0.67 (0.42–1.10) |
| P for interaction | 0.0047 | 0.23 | 0.19 | 0.31 | 0.90 | 0.91 | ||||||
| IR exposure history | ||||||||||||
| No | 333/335 | 1.37 (1.00–1.89) |
332/336 | 0.76 (0.55–1.06) |
329/335 | 0.68 (0.48–1.00) |
332/336 | 0.71 (0.50–1.01) |
331/334 | 1.89 (1.00–3.56) |
331/334 | 0.70 (0.49–1.01) |
| Yes | 35/21 | 3.45 (1.11–11.1) |
35/21 |
0.20 (0.08–0.62) |
35/21 | 0.76 (0.20–2.94) |
35/21 | 0.26 (0.08–0.91) |
35/20 | 1.32 (0.11–16.7) |
34/21 | 0.40 (0.10–1.54) |
| P for interaction | 0.14 | 0.036 | 0.82 | 0.072 | 0.79 | 0.44 | ||||||
| Histological type | ||||||||||||
| High grade | 213/363 |
1.46 (1.01–2.08) |
212/364 | 0.79 (0.54–1.15) |
211/362 | 0.70 (0.46–1.08) |
212/364 | 0.77 (0.51–1.14) |
214/361 |
1.97 (1.00–3.95) |
212/362 |
0.50 (0.32–0.78) |
| Medium grade | 76/363 | 1.15 (0.69–1.90) |
76/364 |
0.52 (0.28–0.95) |
74/362 |
0.52 (0.26–0.99) |
76/364 |
0.47 (0.24–0.88) |
75/361 | 1.77 (0.66–4.71) |
76/362 | 1.32 (0.75–2.30) |
| Low grade | 82/363 | 1.51 (0.91–2.51) |
82/364 | 0.72 (0.41–1.22) |
82/364 | 0.75 (0.42–1.35) |
82/364 | 0.66 (0.38–1.17) |
80/361 | 1.66 (0.63–4.37) |
79/362 | 0.91 (0.51–1.63) |
*
Adjusted for age and gender, accordingly.
†
Numbers of cases/controls.