Table 3.
Odds Ratios for Associations Between Reportedly Obesity-Related Single Nucleotide Polymorphisms and Obesity in Chinese Women, 1996–2007
| Normal Weight (n = 1,863) |
Obesity (n = 830) |
AB vs. AA |
BB vs. AA |
P Valuea | |||||
| SNP | Effective Allele Frequency (Proportion) | AA/AB/BBb | Effective Allele Frequency (Proportion) | AA/AB/BBb | ORc | 95% CI | ORc | 95% CI | |
| rs2815752 | 0.92 | 9/261/1,593 | 0.92 | 4/123/703 | 0.90 | 0.25, 3.28 | 0.89 | 0.25, 3.17 | 0.87 |
| rs10913469 | 0.19 | 1,240/547/72 | 0.23 | 480/311/38 | 1.40 | 1.14, 1.71 | 1.38 | 0.85, 2.24 | 1.6 × 10−3 |
| rs6548238 | 0.90 | 16/332/1,515 | 0.91 | 10/126/694 | 0.56 | 0.23, 1.37 | 0.59 | 0.25, 1.43 | 0.91 |
| rs7647305 | 0.95 | 4/186/1,669 | 0.95 | 1/76/752 | 3.47 | 0.23, 53.0 | 3.21 | 0.21, 48.3 | 0.82 |
| rs10938397 | 0.29 | 912/798/149 | 0.31 | 389/366/74 | 0.91 | 0.74, 1.11 | 1.04 | 0.73, 1.47 | 0.69 |
| rs6235 | 0.33 | 811/858/190 | 0.34 | 349/390/90 | 1.15 | 0.94, 1.40 | 1.16 | 0.84, 1.61 | 0.18 |
| rs4712652 | 0.12 | 1,428/409/22 | 0.12 | 641/178/10 | 0.91 | 0.72, 1.15 | 1.16 | 0.48, 2.81 | 0.56 |
| rs2844479 | 0.54 | 379/934/546 | 0.58 | 154/392/283 | 1.11 | 0.86, 1.44 | 1.46 | 1.12, 1.92 | 3.3 × 10−3 |
| rs4074134 | 0.55 | 372/929/558 | 0.57 | 137/437/255 | 1.34 | 1.04, 1.74 | 1.21 | 0.91, 1.60 | 0.35 |
| rs10838738 | 0.32 | 858/808/193 | 0.35 | 354/371/104 | 1.10 | 0.90, 1.35 | 1.29 | 0.95, 1.76 | 0.10 |
| rs7138803 | 0.28 | 943/802/118 | 0.27 | 441/334/55 | 0.92 | 0.76, 1.12 | 1.13 | 0.76, 1.69 | 0.89 |
| rs7498665 | 0.11 | 1,485/347/27 | 0.14 | 614/199/16 | 1.37 | 1.09, 1.72 | 1.70 | 0.84, 3.46 | 2.7 × 10−3 |
| rs9939609 | 0.11 | 1,478/360/25 | 0.14 | 621/186/23 | 1.23 | 0.97, 1.54 | 2.04 | 1.03, 4.04 | 0.01 |
| rs1424233 | 0.67 | 200/836/823 | 0.67 | 90/373/366 | 1.04 | 0.76, 1.44 | 1.01 | 0.73, 1.40 | 0.95 |
| rs1805081 | 0.24 | 1,064/693/102 | 0.22 | 498/294/37 | 0.91 | 0.75, 1.12 | 0.68 | 0.43, 1.06 | 0.10 |
| rs17782313 | 0.20 | 1,193/607/63 | 0.25 | 464/317/49 | 1.22 | 1.00, 1.49 | 2.16 | 1.39, 3.37 | 7.1 × 10−4 |
| rs29941 | 0.23 | 1,099/661/101 | 0.22 | 496/295/38 | 1.06 | 0.87, 1.30 | 0.86 | 0.55, 1.33 | 0.98 |
Abbreviations: CI, confidence interval; OR, odds ratio; SNP, single nucleotide polymorphism.
P value from an additive logistic regression model adjusted for age, age squared, menopausal status, and sample set. P values were not corrected for multiple tests.
AA indicates homozygosity for the non-risk allele A, AB indicates heterozygosity, and BB indicates homozygosity for the risk allele B (effective allele in Table 2). Four controls and 1 obese case were excluded from the analyses for SNPs not on the Affymetrix array, because they were among 8 samples not imputed for genotypes.
Adjusted for age, age squared, menopausal status, and sample set.