Table 2.
Toxicities (n = 51)a
| Toxicity | Grade (% of Patients) | ||||
|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | ||
| Adrenal insufficiency | — | 1 (2) | 1 (2) | — | |
| Anemia | 28 (55) | 14 (27) | 4 (8) | 1 (2) | |
| Colitis | — | 1 (2) | 3 (6) | 1 (2) | |
| Confusion | — | — | 3 (6) | 1 (2) | |
| Conjunctivitis | — | 2 (4) | — | — | |
| Dehydration | — | — | 3 (6) | — | |
| Diarrhea | 6 (12) | 3 (6) | 8 (16) | — | |
| Dyspnea | 9 (18) | 4 (8) | 4 (8) | 1 (2) | |
| Fatigue | 17 (33) | 9 (18) | 4 (8) | — | |
| Hypothyroidism | — | 1 (2) | — | — | |
| Increased ALT | 9 (18) | 5 (10) | 2 (4) | 2 (4) | |
| Increased AST | 11 (22) | 4 (8) | 2 (4) | 2 (4) | |
| Increased bilirubin | — | — | 2 (4) | 2 (4) | |
| Increased lipase | 1 (2) | — | — | 1 (2) | |
| Infection | — | — | 3 (6) | 2 (4) | |
| Leukopenia | 10 (20) | 1 (2) | — | 1 (2) | |
| Lymphopenia | 6 (12) | 9 (18) | 9 (18) | — | |
| Nausea/vomiting | 15 (29) | 4 (8) | 2 (4) | — | |
| Neutropenia | — | — | — | 1 (2) | |
| Pain | 10 (20) | 8 (16) | 2 (4) | — | |
| Pruritis | 18 (35) | 4 (8) | — | — | |
| Rash | 13 (25) | 5 (10) | 1 (2) | — | |
| Thrombosis | — | — | 1 (2) | 1 (2) | |
| Thrombocytopenia | 1 (2) | 2 (4) | 2 (4) | 1 (2) | |
ALT indicates alanine aminotransferase; AST, aspartate aminotransferase.
aToxicities were graded according to National Cancer Institute Common Terminology Criteria for Adverse Events (version 3.0).