. Author manuscript; available in PMC: 2010 Aug 5.

Published in final edited form as: Cancer Res. 2007 Jul 15;67(14):6582–6590. doi: 10.1158/0008-5472.CAN-06-4145

Table 1.

Protein sequence of human cyclin B1 (NCBI accession number NM_031966) aligned with that of human HER4/s80^HER4, human HER1, human HER2, and human HER3. Residues defining the D-box are bolded and underlined. Site-directed mutagenesis was performed to generate R-to-A and L-to-A mutations, shown in lowercase. * Alignment of ErbB sequences according to Plowman et al., 1993.

Protein name	Amino acid #*	Sequence
Cyclin B1	40-60	RPRTALGDIGNKVSEQLQAKM
HER4/s80^HER4	990-1010
DDRMKLPSPNDSKFFQNLLDE
HER4^db/s80^db	990-1010
DDaMKaPSPNDSKFFQNLLDE
HER1/EGFR	960-980	DERMHLPSPTDSNFYRALMDE
HER2/ErbB2	992-1012	ED - LGP-ASPLDSTFYRSLLED
HER3/ErbB3	930-950	SGPGIAPGPEPHGLTNKKLEE