Table 1.

Enantioselective decarboxylative enolate alkylation cascade^a.

Entry	Substrate	Product	Time	Yieldb	dr(3:4)c	ee(3)	ee(4)
1			24 h	99%	1 : 6.1	77%	87%
2			48 h	91%	1 : 3.5	95%	99%
3d			72 h	88%	1 : 3.4	88%	97%
4			40 h	49%	1 : 1.9	85%	88%
5e			65 h	65%	1 : 1.9	93%	94%
6			24 h	56%	1 : 3.3	82%	89%
7f			24 h	56%	1 : 1.3	69%	70%
8g			72 h	57%	1 : 2.4	75%	81%
9			20 h	97%	1 : > 20	-	89%
10			48 h	99%	1 : > 20	71%	97%

^aGeneral reaction conditions: 1 (0.3–0.5 mmol), 2 (1.0 equiv), [Pd₂(dba)₃] (5 mol%), L2 (12.5 mol%), 1,4-dioxane (0.1 M), 40 °C.

^bCombined isolated yield.

^cDetermined by ¹H nmr.

^dCarried out on 1 mmol scale with 2.5 mol% [Pd₂(dba)₃] and 6.25 mol% L2.

^eReaction performed at 23 °C.

^fPd(pmdba)₂ (10 mol%) was used as precatalyst.

^gReaction performed at 60 °C.