Skip to main content
. 2010;121:34–51.

TABLE 1.

Maladaptive Cardiovascular Effects on Innate Immunity and Proinflammatory Cytokine Signaling

Produces left ventricular dysfunction
Produces pulmonary edema in humans
Produces cardiomyopathy in humans
Promotes left ventricular remodeling experimentally
Produces abnormalities in myocardial metabolism experimentally
Produces β-receptor uncoupling from adenylate cyclase experimentally
Produces abnormalities of mitochondrial energetics
Activation of the fetal gene program experimentally