Fig. 5.

Panel A: Resveratrol improves health and survival of mice on a high-calorie diet. Kaplan-Meier survival curves. Hazard ratio for HCR is 0.69 (χ² = 5.39, P = 0.020) versus HC, and 1.03 (χ² = 0.022, P = 0.88) versus SD. The hazard ratio for HC versus SD is 1.43 (χ² = 5.75, P = 0.016). Panel B: Time to fall from an accelerating rotarod was measured every 3 months for all survivors from a pre-designated subset of each group; n = 15 (SD), 6 (HC) and 9 (HCR). Asterisk, P < 0.05 versus HC; hash, P < 0.05 versus SD. Error bars indicate s.e.m. (Modified with permission from Nature 2006;444:337–42).