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Tnk1/Kos1 uncouples Grb2-Sos1 GEF complex. Receptor mediated Ras activation is regulated by guanine nucleotide exchange factors, which catalyze the exchange of GDP for GTP. The model depicts the mechanism by which activated Tnk1/Kos1 inhibits the Ras GEF activity by uncoupling the activated Grb2-Sos1 GEF complex to indirectly suppress Ras and abort downstream Ras signaling.
