Table 2.

Toxicity Data by Study

	85-31		86-10		92-02
	RT Alone	RT+LTH	RT	RT+STH	RT+STH	RT+LTH
n	467	477	231	223	755	753
Late Max GI - Toxicity
Gr 3	4% (n=17)	2% (n=11)	3% (n=7)	2% (n=4)	1% (n=6)	2% (n=16)
Gr 4	1 %( n=3 )	1 % (n=6)	1 %( n=3 )	<1% (n=1)	<1 %(n=2 )	<1% (n=3)
Gr 5	0%	0%	0%	0%	<1% (n=1)	<1% (n=2
Gr≥3	4% (n=20)	4% (n=17)	4% (n=10)	2% (n=5)	1% (n=9)	3% (n=21)
Late Max GU -Toxicity
Gr3	8% ( n=36)	6% (n=31)	6% (n=15)	7% (n=15)	4% (n=32)	3% (n=26)
Gr4	1% (n=5)	1% (n=4)	2% (n=4)	1% (n=2)	<1% (n=2)	2% (n=13)
Gr5	0%	0%	0%	0%	0%	0%
Gr≥3	9% (n=41)	7% (n=35)	8% (n=19)	8% (n=17)	5% ( n=34)	5% (n=39)
Late Other - Toxicity
Gr 3	1% (n=7)	2%(n=8)	2% (n=3)	<1% (n=1)	1% (n=5)	1% (n=8)
Gr 4	<1% (n=2)	0%	1% (n=2)	0%	0%	<1% (n=1)
Gr 5	0%	0%	0%	0%	0%	0%
Gr≥3	2% (n=9)	2% (n=8)	2% (n=5)	<1% (n=1)	1% (n=5)	1% (n=9)
Max Total Toxicity
Gr3	11% (n=53)	10% (n=50)	8% (n=19)	9% (n=19)	6% (n=42)	6% (n=46)
Gr4	2% (n=10)	2% (n=9)	3% (n=6)	1% (n=3)	1% (n=4)	2% (n=15)
Gr 5	0%	0%	0%	0%	< 1% (n=1)	< 1% (n=2)
Gr≥3	13% (n=63)	12% (n=59)	11% (n=25)	10% (n=22)	6% (n=47)	8% (n=63)