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. Author manuscript; available in PMC: 2010 Aug 6.
Published in final edited form as: J Nucl Med. 2010 Apr;51(4):632–638. doi: 10.2967/jnumed.109.071233

Figure 4.

Figure 4

(A) Comparison of HT29 peritoneal tumors from animals breathing air or carbogen (95% O2, 5% CO2). 18F-FDG uptake and pimonidazole binding were markedly reduced for carbogen breathing whereas GLUT-1 expression was unaffected (see text for details). Scale bar 500 μm. (B) For air breathing conditions, overall 18F-FDG uptake was higher and a number of “hot spots” were observed. In contrast, carbogen breathing (C) resulted in significantly less18F- FDG uptake in microscopic tumors. Similar results were seen in 4 carbogen-breathing animals. Scale bars 4 mm. (D) The difference in 18F-FDG uptake between sub-millimeter HT29 tumors in air-breathing (9 tumors from 2 animals) and carbogen-breathing (11 tumors from 2 animals) animals was significant p<0.001.