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Decreased cathepsin K and osteocalcin expression in both th3/+ and th3/th3 mice compared to controls. Total mRNA was prepared from femurs after bone marrow was flushed. Levels of expression were normalized to the mouse HPRT housekeeping gene. Values are expressed as mean ± SD. WT wild-type, shown as white bars; IR irradiated control, shown as gray-patterned bars; th3/+ shown as gray bars; th3/th3 shown as black bars. *P < 0.05, **P < 0.01
