Figure 4.

Longitudinal μCT analysis of th3/+ mice. a μCT analysis of trabecular (first row) and cortical (second row) bone. Percent increase or decrease of various μCT parameters of th3/+ animals compared to age-matched controls was calculated. Animals were studied at ages 2, 4, 6, and 9 months (n = 6/group). μCT changes were present by 2 months and did not worsen by 9 months. Error bars represent SDs. b Representative μCT images of th3/+ and their controls at 2 and 9 months: vertical sections of vertebral body at L5 (first row) and cortical bone at mid-diaphysis femor (second row). Affected animals manifest thinning of trabeculae and thinner cortices. Comparison of images at 2 and 9 months does not indicate progressive disease, indicating that these bone abnormalities develop early during the period of bone accrual