Table 2.

Common (count ≥ 3) DRB1-DQA1-DQB1 estimated haplotypes in study cohorts

	RF negative polyarticular			Oligoarticular persistent			Oligoarticular extended	Combined		Controls
	All	<6 yrs*	≥6 yrs	All	<6 yrs	≥6 yrs	All	<6 yrs	≥6 yrs
Haplotype	freq (n)	freq (n)	freq (n)	freq (n)	freq (n)	freq (n)	freq (n)	freq (n)	freq (n)	freq (n)
0101-101-0501	0.128 (85)	0.112 (34)	0.152 (50)	0.105 (74)	0.111 (52)	0.090 (19)	0.099 (25)	0.112 (109)	0.116 (75)	0.09 (49)
0102-0101-0501	0.012 (8)	0.007 (2)	0.018 (6)	0.013 (9)	0.011 (5)	0.019 (4)	0.004 (1)	0.008 (8)	0.015 (10)	0.009 (5)
0103-0101-501	0.006 (4)	0.003 (1)	0.009 (3)	0.004 (3)	0.004 (2)	0.005 (1)	0.008 (2)	0.005 (5)	0.006 (4)	0.018 (10)
0301-0400-0201	0.002 (1)	0.003 (1)	0	0.004 (3)	0.006 (3)	0	0.008 (2)	0.006 (6)	0	0
0301-0500-0201	0.107 (71)	0.099 (30)	0.115 (38)	0.116 (82)	0.126 (59)	0.099(21)	0.075 (19)	0.107 (104)	0.105 (68)	0.112 (61)
0401-0300-0301	0.033 (22)	0.030 (9)	0.036 (12)	0.018 (13)	0.011 (5)	0.028 (6)	0.020 (5)	0.017 (17)	0.036 (23)	0.049 (27)
0401-0300-0302	0.029 (19)	0.023 (7)	0.033 (11)	0.011 (8)	0.006 (3)	0.019 (4)	0.044 (11)	0.017 (17)	0.033 (21)	0.035 (19)
0402-0300-0302	0.002 (1)	0	0.003 (1)	0.004 (3)	0.006 (3)	0	0.004 (1)	0.003 (3)	0.003 (2)	0.011 (6)
0403-0300-0302	0.006 (4)	0.007 (2)	0.006 (2)	0.008 (6)	0.009 (4)	0.009 (2)	0.012 (3)	0.009 (9)	0.006 (4)	0.004 (2)
0404-0300-0302	0.024 (16)	0.020 (6)	0.027 (9)	0.008 (6)	0.002 91)	0.024 (5)	0.012 (3)	0.009 (9)	0.025 (16)	0.029 (16)
0701-0201-0201	0.054 (36)	0.049 (15)	0.061 (20)	0.028 (20)	0.017 (8)	0.052 (11)	0.067 (17)	0.036 (35)	0.059 (38)	0.081 (44)
0701-0201-0303	0.026 (17)	0.020 (6)	0.03 (10)	0.014 (10)	0.013 (6)	0.014 (3)	0.004 (1)	0.013 (13)	0.023 (15)	0.031 (17)
0801-0400-0402	0.08 (53)	0.102 (31)	0.064 (21)	0.137 (97)	0.152 (71)	0.099(21)	0.099 (25)	0.128 (125)	0.077 (50)	0.02 (11)
0801-0600-0301	0.003 (2)	0.007 (2)	0	0.004 (3)	0.006 (3)	0	0	0.005 (5)	0	0
0805-0400-0402	0.003 (2)	0.003 (1)	0.003 (1)	0.004 (3)	0.006 (3)	0	0.004 (1)	0.004 (4)	0.003 (2)	0
0901-0300-0303	0.012 (8)	0.016 (5)	0.009 (3)	0.010 (7)	0.009 (4)	0.014 (3)	0.012 (3)	0.012 (12)	0.009 (6)	0.007 (4)
1001-0101-0501	0.009 (6)	0.007 (2)	0.012 (4)	0.003 (2)	0	0.005 (1)	0	0.003 (3)	0.009 (6)	0.007 (4)
1101-0500-0301	0.057 (38)	0.069 (21)	0.036 (12)	0.078 (55)	0.081 (38)	0.075(16)	0.079 (20)	0.076 (74)	0.06 (39)	0.064 (35)
1103-0500-0301	0.026 (17)	0.033 (10)	0.021 (7)	0.017 (12)	0.017 (8)	0.014 (3)	0.008 (2)	0.025 (24)	0.02 (13)	0
1104-0103-0603	0	0	0	0.005 (4)	0.006 (3)	0	0	0.003 (3)	0	0
1104-0500-0301	0.059 (39)	0.092 (28)	0.024 (8)	0.073 (52)	0.083 (39)	0.057 (12)	0.087 (22)	0.085 (83)	0.048 (31)	0.02 (11)
1201-0500-0301	0.012 (8)	0.016 (5)	0.009 (3)	0.010 (7)	0.006 (3)	0.019 (4)	0.029 (7)	0.012 (12)	0.015 (10)	0.015 (8)
1301-0103-0603	0.074 (49)	0.095 (29)	0.055 (18)	0.121 (86)	0.130 (61)	0.104 (22)	0.075 (19)	0.11 (107)	0.073 (47)	0.057 (31)
1302-0102-0604	0.020 (13)	0.026 (8)	0.015 (5)	0.035 (25)	0.041 (19)	0.019 (4)	0.02 (5)	0.032 (31)	0.019 (12)	0.027 (15)
1303-0500-0301	0.012 (8)	0.020 (6)	0.006 (2)	0.013 (9)	0.015 (7)	0.009 (2)	0.008 (2)	0.014 (14)	0.008 (5)	0.016 (9)
1401-0101-0503	0.041 (27)	0.036 (11)	0.042 (14)	0.013 (9)	0.015 (7)	0.009 (2)	0.016 (4)	0.023 (22)	0.028 (18)	0.029 (16)
1501-0102-0602	0.080 (53)	0.046 (14)	0.109 (36)	0.048 (34)	0.034 (16)	0.085 (18)	0.075 (19)	0.046 (45)	0.094 (61)	0.147 (80)
1501-0102-0603	0.002 (1)	0	0.003 (1)	0.004 (3)	0.006 (3)	0	0.004 (1)	0.004 (4)	0.002 (1)	0
1502-0102-0602	0.003 (2)	0.003 (1)	0.003 (1)	0.006 (4)	0.002 (1)	0.014 (3)	0.004 (1)	0.003 (3)	0.006 (4)	0.011 (6)
1601-0102-0502	0.008 (5)	0.010 (3)	0.006 (2)	0.008 (6)	0.013 (6)	0	0.012 (3)	0.011 (11)	0.005 (3)	0.015 (8)

^*Age at disease onset.