Figure 2a.

Fitted mean (with 95% confidence intervals) standardized global cognition test scores over time from women grouped by WHI treatment assignment with adjustment for baseline 3MS score, trial (CEE+MPA vs CEE-Alone), age, education, race/ethnicity, smoking status, body mass index, hypertension, alcohol intake, prior cardiovascular disease, diabetes, prior use of hormone therapy, and prior use of oral contraceptives. The left-hand axis provides units in the original scale. The lower panel provides the number of women who contributed to each data point and the percentage of measurements that were collected during on-trial.