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. 2010 Jul 21;2:25. doi: 10.3389/fnagi.2010.00025

Table 1.

Differences and similarities between AD and PD.

AD PD
DIFFERENCES
Dementia disorder Movement disorder
Tangles and Plagues made up of Tau and Aβ Lewy bodies made up of alpha-synuclein and ubiquitin
Genetic mutation in APP, PSEN1, Genetic mutation in α-synuclein,
PSEN2, ApoE Parkin, PINK1, LRRK2 and DJ-1
SIMILARITIES
Presence of misfolded and insoluble proteins
Axonal transport dysfunction
Iron induced oxidative stress
Dysfunctional L-type voltagegated calcium channel