Table 1.
AD | PD |
---|---|
DIFFERENCES | |
Dementia disorder | Movement disorder |
Tangles and Plagues made up of Tau and Aβ | Lewy bodies made up of alpha-synuclein and ubiquitin |
Genetic mutation in APP, PSEN1, | Genetic mutation in α-synuclein, |
PSEN2, ApoE | Parkin, PINK1, LRRK2 and DJ-1 |
SIMILARITIES | |
Presence of misfolded and insoluble proteins | |
Axonal transport dysfunction | |
Iron induced oxidative stress | |
Dysfunctional L-type voltagegated calcium channel |