Table 1.
The properties of mIPSC in CA1 neurons undergoing SE
Parameter | Con | SE | SE + Pep_3 | SE + Pep_3P | PDBU | PDBU + CalC | CalC |
---|---|---|---|---|---|---|---|
Peak amplitude (pA) at 2 min | 46.6 ± 2.6 | 37.3 ± 1.8 | 36.2 ± 3.1 | 38.0 ± 3. | 3 35.3 ± 3.2 | 39.2 ± 3.5 | 36.0 ± 3.9 |
Peak amplitude (pA) at 22 min | 48.5 ± 3.8 | 39.5 ± 1.9 | 53.9 ± 7.5* | 38.4 ± 3.1 | 51.5 ± 4.6* | 40.6 ± 3.9 | 37.1 ± 4.1 |
10–90% rise time (ms) | 1.4 ± 0.1 | 1.4 ± 0.2 | 1.3 ± 0.2 | 1.4 ± 0.1 | 1.5 ± 0.1 | 1.4 ± 0.1 | 1.5 ± 0.2 |
τ decay (ms) at 2 min | 16.9 ± 1.1 | 17.4 ± 1.1 | 15.9 ± 0.9 | 16.3 ± 1.4 | 15.3 ± 0.9 | 14.6 ± 2.3 | 19.0 ± 0.5 |
τ decay (ms) at 22 min | 17.9 ± 0.9 | 18.3 ± 1.1 | 21.7 ± 1.3* | 18.2 ± 1.7 | 21.3 ± 1.9* | 16.2 ± 2.5 | 21.9 ± 0.9 |
Frequency | 2.1 ± 0.4 | 1.7 ± 0.2 | 2.1 ± 0.3 | 1.8 ± 0.4 | 1.2 ± 0.35 | 1.6 ± 0.3 | 1.2 ± 0.35 |
The kinetic parameters of mIPSCs of CA1 neurons in the absence and presence of peptides, PKC inhibitors, and activators were calculated at both 0 time and 20 min. In all panels, asterisks indicate significant difference from control (Con; p < 0.01; n = 8–12).