Figure 1.

SE stimulates astrocytic Ca²⁺ signals. A, B, The time course of somatic Ca²⁺ signals recorded simultaneously in four astrocytes before (A) and after (B) acute injection of pilocarpine to the anesthetized mouse. Astrocytic Ca²⁺ signals (3 examples from 3 mice in each condition) recorded 3 d after a subthreshold injection of pilocarpine (Control) (C) or 3 d after SE (D). E, Time course of change in Ca²⁺ signals after SE reported as the integral of the ΔF/F₀ signal (*p < 0.05; **p < 0.00005; n value is between 4 and 8 animals for each time point). Error bars indicate SEM.