. Author manuscript; available in PMC: 2010 Aug 6.

Published in final edited form as: Ann Endocrinol (Paris). 2010 Apr 2;71(3):144–148. doi: 10.1016/j.ando.2010.02.020

Table 1.

Mouse models with defects in cumulus expansion. For more detailed information, refer to reference [4].

Gene (symbol)	Fertility status	Ref
Prostaglandin-endoperoxide synthase 2 (Ptgs2; Cox2)	Mostly infertile	[22,23]
Prostaglandin E receptor 2, subtype EP2 (Ptger2)	Subfertile	[24–26]
Pentraxin 3 (Ptx3)	Subfertile	[27,28]
Tumor necrosis factor α induced protein 6 (Tnfaip6)	Infertile	[29]
Sulfotransferase family 1E, member 1 (Sult1e1)	Subfertile	[30,31]
Alpha 1 microglobulin/bikunin (Ambp)	Subfertile	[32,33]
Amphiregulin (Areg)	Subfertile	[34]
Bone morphogenetic protein 15 (Bmp15)	Subfertile	[35]
Bone morphogenetic protein receptor, type IB (Bmpr1b)	Subfertile	[36]
Epiregulin (Ereg^wa²^/wa²; hypomorph)	Subfertile	[34]
Mitogen-activated protein kinases 3 and 1 (Mapk3^−/− Mapk1 cKO)	Infertile	[37]
Nuclear receptor subfamily 5, group 2, member 1 (Nr5a1; Sf1, steroidogenic factor 1) (cKO)	Infertile	[38]
Nuclear receptor subfamily 5, group 2, member 2 (Nr5a2; Lrh1, liver receptor homolog 1) (cKO)	Infertile	[39]

cKO: conditional knockout.