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. Author manuscript; available in PMC: 2010 Aug 6.
Published in final edited form as: Ann Endocrinol (Paris). 2010 Apr 2;71(3):144–148. doi: 10.1016/j.ando.2010.02.020

Table 1.

Mouse models with defects in cumulus expansion. For more detailed information, refer to reference [4].

Gene (symbol) Fertility status Ref
Prostaglandin-endoperoxide synthase 2 (Ptgs2; Cox2) Mostly infertile [22,23]
Prostaglandin E receptor 2, subtype EP2 (Ptger2) Subfertile [2426]
Pentraxin 3 (Ptx3) Subfertile [27,28]
Tumor necrosis factor α induced protein 6 (Tnfaip6) Infertile [29]
Sulfotransferase family 1E, member 1 (Sult1e1) Subfertile [30,31]
Alpha 1 microglobulin/bikunin (Ambp) Subfertile [32,33]
Amphiregulin (Areg) Subfertile [34]
Bone morphogenetic protein 15 (Bmp15) Subfertile [35]
Bone morphogenetic protein receptor, type IB (Bmpr1b) Subfertile [36]
Epiregulin (Eregwa2/wa2; hypomorph) Subfertile [34]
Mitogen-activated protein kinases 3 and 1 (Mapk3−/− Mapk1 cKO) Infertile [37]
Nuclear receptor subfamily 5, group 2, member 1 (Nr5a1; Sf1, steroidogenic factor 1) (cKO) Infertile [38]
Nuclear receptor subfamily 5, group 2, member 2 (Nr5a2; Lrh1, liver receptor homolog 1) (cKO) Infertile [39]

cKO: conditional knockout.