Table 1.

The two dichotomies that help position therapies are based on properties of the therapy. One is whether the therapy is localized or generalized. The latter includes both systemic and total skin treatments. The second property is whether the treatment is administered with a primary intent of reducing tumor burden to zero (remittive) or whether it is to improve quality of life (palliative). While there have been infrequent remissions with some of the palliative therapies, a cut off of 50% remission rate was used to define the treatments in the far right column.

	Palliative	Remittive
Localized	Steroid Cream	X-ray Bexarotene Gel Excimer Laser Imiquimod Cryotherapy Surgical Excision
Generalized	Prednisone Chlorambucil Methotrexate Photopheresis Oral Bexarotene Oral Vorinostat Denileukin Diftitox Romidepsin Liposomal Doxorubicin Alemtuzimab	Nitrogen Mustard Total Skin Electron Beam Phototherapy Allogeneic Stem Cell Transplantation