Table 4.
Multivariate Analysis for 3-Year Survival
| Variable by Disease | No. of Patients | Death Outcome |
P* | |
|---|---|---|---|---|
| Relative Risk | 95% CI | |||
| AML | ||||
| Disease status at transplantation | Poverall < .001 | |||
| Primary induction failure | 636 | 1.00 | ||
| Duration of first CR ≤ 6 months | 514 | 1.26 | 1.06 to 1.51 | .01† |
| Duration of first CR > 6 months | 414 | 0.83 | 0.69 to 0.99 | .0401 |
| Duration of first CR unknown | 100 | 0.92 | 0.68 to 1.24 | .5987 |
| Blasts in blood at transplantation | Poverall < .001 | |||
| Absent | 749 | 1.00 | ||
| Present | 673 | 1.48 | 1.28 to 1.72 | .0000 |
| Missing/negative | 242 | 1.27 | 0.98 to 1.64 | .0753 |
| Donor-recipient HLA match | Poverall < .001 | |||
| HLA-identical sibling | 544 | 1.00 | ||
| Other related | 117 | 2.21 | 1.51 to 3.23 | .0000* |
| Well-matched unrelated | 354 | 1.25 | 1.02 to 1.54 | .0279 |
| Partially matched unrelated | 419 | 1.15 | 0.96 to 1.38 | .1426 |
| Mismatched unrelated | 230 | 1.46 | 1.15 to 1.84 | .0017 |
| Karnofsky or Lansky score | Poverall < .001 | |||
| < 90 | 754 | 1.00 | ||
| 90-100 | 832 | 0.65 | 0.56 to 0.76 | .0000 |
| Missing | 78 | 0.58 | 0.42 to 0.81 | .0012 |
| Cytogenetics* | Poverall = .0226 | |||
| Good | 117 | |||
| Intermediate | 981 | 1.13 | 0.86 to 1.50 | .3791 |
| Poor | 272 | 1.47 | 1.06 to 2.04 | .0225 |
| Unknown | 294 | 1.37 | 1.00 to 1.89 | .0528 |
| ALL | ||||
| Disease status at transplantation | Poverall = .0003 | |||
| Primary induction failure | 144 | 1.00‡ | ||
| First untreated relapse | 67 | 1.34 | 0.83 to 2.15 | .2312 |
| First refractory relapse | 251 | 2.10 | 1.43 to 3.09 | .0002 |
| Second and additinoal relapse | 111 | 2.58 | 1.53 to 4.34 | .0004 |
| Blasts in marrow at transplantation, % | Poverall = .0014 | |||
| < 25 | 277 | 1.00‡ | ||
| ≥ 25 | 211 | 1.75 | 1.18 to 2.58 | .0053 |
| Missing | 94 | 2.21 | 1.34 to 3.66 | .0020 |
| Donor/recipient CMV status | Poverall = .0058 | |||
| −/− | 151 | 1.00‡ | ||
| +/− | 76 | 1.66 | 0.99 to 2.80 | .0555 |
| −/+ | 145 | 1.06 | 0.73 to 1.53 | .7718 |
| +/+ | 192 | 2.28 | 1.43 to 3.63 | .0005 |
| Missing | 18 | 0.95 | 0.43 to 2.10 | .9039 |
| Age, years | Poverall < .001 | |||
| < 1-9 | 55 | 1.00‡ | ||
| 10-19 | 102 | 1.76 | 1.03 to 3.02 | .0403 |
| 20-29 | 146 | 1.75 | 1.06 to 2.91 | .0296 |
| 30-39 | 127 | 1.57 | 0.95 to 2.60 | .0769 |
| 40-49 | 105 | 4.75 | 2.37 to 9.53 | < .001 |
| 50-59 | 46 | 1.46 | 0.79 to 2.70 | .2309 |
Abbreviations: AML, acute myeloid leukemia; CR, complete remission; ALL, acute lymphoblastic leukemia; CMV, cytomegalovirus.
*
P shown overall and as pairwise comparisons with reference group.
†
Pairwise comparison: duration of first CR < 6 months v > 6 months (P < .001).
‡
Reference group.