Table 1.

Association of BRCAness Profile With BRCA2 Mutation Status, RAD51 Foci Formation After Radiation and PARP Inhibitor Responsiveness

Capan-1 Clone	BRCA2 Status	RAD51 Foci Formation*	PARP Inhibitor Responsiveness†	Profile
C2-1	Revertant‡	Yes	ND	NBL
C2-2	Revertant	Yes	ND	NBL
C2-4	Revertant	Yes	ND	NBL
C2-14	Revertant	Yes	Resistant	NBL
C2-12	Revertant	Yes	Resistant	NBL
C2-5	Revertant	Yes	ND	BL
C2-16	Mutated§	Yes	ND	BL
C2-10	Mutated	No	Sensitive	BL
C2-13	Mutated	No	Sensitive	BL
C2-15	Mutated	No	ND	BL
C2-18	Mutated	No	ND	BL
C2-8	Mutated	No	ND	NBL

Abbreviations: PARP, poly-ADP ribose polymerase; ND, not determined; NBL, non–BRCA-like; BL, BRCA-like.

^*Ability to form RAD51 formation after ionizing radiation, as previously described.²⁹

^†PARP inhibitor responsiveness in vitro, as previously described.²⁹

^‡Revertant refers to clones harboring secondary BRCA2 mutations that cancel the effect of the inherited 6174delT BRCA2 mutation and lead to functional BRCA2 isoforms.

^§Mutated refers to clones harboring only the original 6174delT BRCA2 mutation without acquiring a secondary mutation that restored BRCA2 function.