Table 3.

Invasive Breast Cancer Tumor Characteristics by Bisphosphonate Use

Characteristic	Bisphosphonate Use				P
	No		Yes
	No.	%	No.	%
SEER stage
Localized	3,700	75.1	42	71.2
Regional	1,176	23.9	16	27.1	.74
Distant	52	1.1	1	1.7
Missing	164	3.2	5	7.8	.04
Grade
Well differentiated	1,240	28.0	12	20.3
Moderately differentiated	1,890	42.7	30	50.8	.54
Poorly differentiated	1,164	26.3	15	25.4
Anaplastic	137	3.1	2	3.4
Missing	661	13.0	5	7.8	.22
Histology
Infiltrating ductal	3,182	63.4	33	53.2
Lobular	487	9.7	4	6.5
Infiltrating ductal and lobular carcinoma	705	14.0	16	25.8	.06
Tubular	183	3.6	4	6.5
Other	465	9.3	5	8.1
Missing	70	1.4	2	3.1	.22
Hormone receptor status
Estrogen receptor assay
Positive	3,829	84.0	50	86.2	.85
Negative	717	15.7	8	13.8
Borderline	13	0.3	0	0.0
Missing	533	10.5	6	9.4	.78
Progesterone receptor assay
Positive	3,126	69.7	42	75.0	.42
Negative	1,327	29.6	13	23.2
Borderline	34	0.8	1	1.8
Missing	605	11.9	8	12.5	.88

Abbreviation: SEER, Surveillance, Epidemiology, and End Results.