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. Author manuscript; available in PMC: 2010 Aug 6.
Published in final edited form as: Invest Ophthalmol Vis Sci. 2004 Dec;45(12):4583–4591. doi: 10.1167/iovs.04-0686

Figure 7.

Figure 7

CK2 inhibitors significantly reduced retinal neovascularization. (A) Fluorescein-dextran perfusion of retinas from mice treated intraperitoneally with solvent (vehicle) or inhibitor (emodin). (B) Hematoxylin-eosin–stained sections of retinas from mice treated with vehicle or TBB. Arrows: neovascular tufts in vehicle-treated retinas. (C) Counts of preretinal nuclei in various groups of mice. Neovascularization is significantly decreased in all inhibitor-treated groups without visibly affecting the main vascular tree. N, number of mice in a group. Five to 10 sections per eye from each mouse were counted. Emodin was used at 30 or 60 mg/kg per day with similar results and TBB at 60 mg/kg per day. *P < 0.001 versus untreated or vehicle.