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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Neuron. 2010 May 27;66(4):493–500. doi: 10.1016/j.neuron.2010.04.012

Figure 1.

Figure 1

Experimental design. (A) Mice were chronically implanted with an electrode and a cannula in binocular visual cortex at P24. Following habituation to the recording apparatus (P25–27), baseline VEPs were recorded at P28 and mice were monocularly deprived for 3 days. At P31, the eye was reopened and VEPs were recorded. After baseline recordings, 0.5 μL of BMI or muscimol+SCH50911 (hereafter referred to as muscimol+) was infused at a rate of 6 μL/hr for 5 min and VEPs were continuously recorded for 1 hour. Final recordings (for BMI only) were made approximately 4 hrs post drug infusion in order to allow for a complete washout of the drug. (B) Diagram of recording electrode and cannula placement in the visual cortex. The recording electrode was implanted at a depth of 450 μm and the cannula was implanted at a depth of 150 μm at a 45° angle to the electrode.