Table 6. Number of mutations found along the mtDNA molecule regions in AD patients (N = 936) vs controls (N = 776).
mtDNA region | N. mutations in AD (N = 534) | N. mutations in CNT (N = 261) |
D-loop | 235 | 115 |
ND1 | 4 | 2 |
ND2 | 44 | 24 |
COI | 3 | 3 |
COII | 5 | 3 |
ATPase8 | 1 | 1 |
ATPase6 | 41 | 24 |
COIII | 1 | 0 |
ND3 | 6 | 2 |
ND4L | 1 | 1 |
ND4 | 7 | 6 |
ND5 | 16 | 5 |
ND6 | 4 | 2 |
CytB | 52 | 25 |
Total (genes) | 185 | 98 |
Y | 1 | 0 |
R | 5 | 5 |
T | 2 | 0 |
C | 1 | 0 |
Q | 19 | 6 |
K | 3 | 0 |
F | 2 | 0 |
S | 1 | 0 |
S2 | 0 | 1 |
Total (tRNA) | 34 | 12 |
12S | 80 | 36 |
Total (rRNA) | 80 | 36 |