Table 4.
Univariate and multivariate (backward conditional selection) Cox regression analysis of metastasis-free survival (MFS) in breast cancer patients considering clinicopathological characteristics, tumour microvessel density and hypoxia inducible factor 1α (HIF-1α)TAG mRNA levels
| Characteristics | Univariate analysis of MFS, Exp B (95% CI) |
P value | Multivariate analysis of MFS, Exp B (95% CI) |
P value |
|---|---|---|---|---|
| Age, years: | ||||
| < 50 | 1 | 0.561 | ||
| ≥ 50 | 1.32 (0.52 to 3.37) | |||
| Positive lymph node: | ||||
| 0 | 1 | 0.003 | 1 | 0.005 |
| 1 to 3 | 8.00 (2.56 to 24.81) | 5.56 (1.75 to 17.63) | ||
| 4 to 9 | 7.50 (1.70 to 30.00) | 6.68 (1.48 to 30.14) | ||
| > 10 | 1.20 (0.14 to 10.00) | 0.48 (0.05 to 4.25) | ||
| Pathological tumour size, mm: | ||||
| < 10 | 1 | 0.39 | ||
| 10 to 20 | 1.10 (0.10 to 8.70) | |||
| 21 to 49 | 2.40 (0.30 to 18.90) | |||
| > 50 | 2.70 (0.20 to 42.90) | |||
| Tumour grade: | ||||
| 1/2 vs | 1 | 0.24 | ||
| 3 | 1.70 (0.70 to 4.40) | |||
| Peritumoural vascular invasion: | ||||
| Absent | 1 | 0.104 | ||
| Present | 3.40 (0.80 to 14.80) | |||
| OR status: | ||||
| Positive | ||||
| Negative | 0.33 (0.13 to 0.85) | 0.021 | ||
| PgR status: | ||||
| Positive | ||||
| Negative | 0.20 (0.07 to 0.60) | 0.005 | 0.23 (0.07 to 0.72) | 0.012 |
| Tumour microvessel density | 1.02 (0.07 to 0.60) | 0.22 | ||
| HIF-1αTAG mRNA levels | 1.03 (1.00 to 1.05) | 0.01 |
OR = oestrogen receptor; PgR = progesterone receptor, Exp B = exponential of beta