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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: J Proteome Res. 2010 Jul 2;9(7):3583–3589. doi: 10.1021/pr1001115

Figure 3.

Figure 3

Identification of crosslinked peptide isotope distributions. A candidate peptide isotope distribution (A) is analyzed by Hardklör. Possible isotope signatures are modeled for (B-i) natural isotope abundance, (B-ii) 18O2, and (B-iii) 18O4 containing peptides. A best match to an 18O4 containing peptide (C) indicates an interpeptide crosslink whose sequences are then identified by PepLynx.