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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: J Allergy Clin Immunol. 2010 Aug;126(2):332–337.e2. doi: 10.1016/j.jaci.2010.05.013

Fig 1. Defective TLR induced cytokine production and absent IL-1 induced signaling associated with IRAK-4 deficiency.

Fig 1

Fig 1

A) TNFα production in PBMCs in response to TLR ligands or PMA + ionomycin. n.d.=not detected B) Control and patient fibroblasts were stimulated for the times shown with IL-1β (10 ng/ml) or TNFα (20 ng/ml). Lysates were analyzed by Western blot with anti-IκBα, anti-phospho p38 MAPK, anti-IRAK-4, and anti-NEMO (loading control). Data are representative of 2 independent experiments.