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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Cancer Prev Res (Phila). 2010 Jul 27;3(8):900–909. doi: 10.1158/1940-6207.CAPR-09-0131

Figure 1. Model of genetic instability and progression in head and neck cancer.

Figure 1

Genetic instability increases and accumulates as a lesion acquires its malignant potential. With increasing heterogeneity of genetic instability, inactivation of tumor suppressor genes and activation of oncogenes account for the phenotypic changes of SCCHN carcinogenesis through normal histology, hyperplasia, dysplasia, carcinoma in situ and invasive carcinoma.