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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: J Mol Cell Cardiol. 2010 May 13;49(3):362–369. doi: 10.1016/j.yjmcc.2010.05.001

Figure 8. The P2Y2 receptor is the predominant P2Y receptor expressed in cardiac fibroblasts.

Figure 8

(A) Quantification of the mRNA for P2Y1, P2Y2, P2Y4, P2Y6 and P2Y12 reveals that the P2Y2 receptors are the most highly expressed P2Y receptor subtype in rat CFs. P2Y2 mRNA expression is 50-, 3.5-, and 11-fold higher than that of P2Y4, P2Y6 and P2Y1 receptors, respectively (p < 0.001). (B) Immunoblotting with a P2Y2 antibody detects P2Y2 receptors in CFs but not human platelets. (C) Sections of left ventricles from rats were stained for DDR2 (red), P2Y2 receptor (green) and nuclei with DAPI (blue). Cross-sectional images of cardiac myocytes and fibroblasts are shown.