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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: Neurosci Res. 2010 Jun 8;68(1):1–8. doi: 10.1016/j.neures.2010.06.001

Fig. 1. Repeated AMPH administration induces behavioral sensitization in rats.

Fig. 1

Rats were injected daily with saline or AMPH for 7 days (1.25 mg/kg for the first and last injections; 4 mg/kg for the middle 5 daily injections). Locomotor activity in response to the first and last injections of AMPH was tested at day 1 and 7, respectively (n = 8–10 per group). Note that the locomotor response to the last injection of AMPH observed at day 7 was significantly greater than that to the first injection of AMPH at day 1, confirming the development of behavioral sensitization following repeated drug administration.