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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Nat Med. 2010 Jul 18;16(8):915–920. doi: 10.1038/nm.2182

Fig. 3. Microneedle immunization studies.

Fig. 3

(a) 12 mice were immunized IM with inactivated influenza virus (A/PR/8/34) or using a microneedle patch encapsulating the same amount of virus. Sera were sampled 14 and 28 days after immunization to determine anti-influenza IgG titers. (b) IgG1 titers (c) IgG2a titers (d) HAI titers on days 14 and 28. (e) Survival rates of immunized and naïve mice upon lethal challenge with 5xLD50 of homologous influenza virus. (f) Percentage of body weight changes upon lethal challenge. Groups: N: naïve group; IM: intramuscularly immunized group; MN: microneedle immunized group; Inf.: unimmunized challenged group.

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