Skip to main content
. Author manuscript; available in PMC: 2011 Jul 23.
Published in final edited form as: J Nat Prod. 2010 Jul 23;73(7):1196–1202. doi: 10.1021/np900633j

Figure 5.

Figure 5

Dose-dependent effects of withanolide A (1) on targets involved in Aβ degradation (IDE and NEP). Cortical neurons were treated with 0, 5, 20 and 100 μM of 1 for 24 h. Immunoblots show significant up-regulation of IDE, while NEP remained unaffected, in neurons treated with 1 in a dose-dependent manner as compared to controls. Histograms corresponding to IDE and NEP blots represent quantitative determinations of intensities of the relevant bands normalized to actin. Data represent mean ± S.D. of three independent experiments. The Student’s t-test was used for analyzing the differences between the two treatment groups (*, p <0.05 compared with respective control).