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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: J Mol Cell Cardiol. 2010 May 23;49(3):449–458. doi: 10.1016/j.yjmcc.2010.05.006

Figure 1. Characterization of the N2B KO mouse model.

Figure 1

(A) Titin expression in LV myocardium of WT and N2B KO mice (1% agarose gels). WT myocardium of the mouse expresses predominately N2B titin with a small level of N2BA titin. In the KO both N2B titin and N2BA titin have a slightly higher mobility than in the WT, consistent with the excision of the N2B element. (B) Titin-based passive tension in WT and N2B KO skinned myocardium (results from 8 WT and 8 KO mice). (Tension is steady-state tension and was measured after 5 min stress relaxation.) Asterisks: comparison between KO and WT myocardium.