Table 1. Cardiovascular Parameters.
The hemodynamic and anatomic responses to Ang-II infusion were not affected by deletion of MCP-1. There was no significant difference between the changes in WT and MCP-1-KO mice in the parameters measured (t-test; P< 0.05; for each individual animal, the % change was calculated with parameters measured before and after 6 wks Ang-II infusion). BW: body weight, HR: heart rate, LVEDV: left ventricular end diastolic volume; LVEDD: LV end diastolic diameter, LVAW-d: LV anterior wall thickness during diastole, LVPW-d: LV posterior wall thickness during diastole, EF: ejection fraction; E-Peak V: early transmitral filling velocity; IVRT / R-R: isovolumic relaxation time corrected by the time per heartbeat.
| WT | MCP-1-KO | |||||
|---|---|---|---|---|---|---|
| pre | 6 wks | % change | pre | 6 wks | % change | |
| Global Parameters | ||||||
| n | 13 | 13 | 13 | 14 | 14 | 14 |
| BW, g | 23.1 ± 0.3 | 27.9 ± 0.4* | 21 ± 2 | 23.8 ± 0.4 | 27.4 ± 0.5* | 15 ± 2 |
| HR, bpm | 404 ± 13 | 417 ± 13 | 4 ± 4 | 382 ± 9 | 411 ± 13 | 8 ± 3 |
| Cardiac Remodeling Parameters | ||||||
| LVEDV, ul | 78 ± 1 | 77 ± 5 | -1 ± 7 | 79 ± 3 | 68 ± 4 | -12 ± 7 |
| LVEDD, mm | 4.18 ± 0.03 | 4.13 ± 0.12 | -1 ± 3 | 4.20 ± 0.06 | 3.92 ± 0.10 | -6 ± 3 |
| LVAW-d, mm | 0.79 ± 0.04 | 1.05 ± 0.04* | 38 ± 8 | 0.90 ± 0.05 | 1.06 ± 0.05 | 22 ± 9 |
| LVPW-d, mm | 0.75 ± 0.04 | 0.87 ± 0.04 | 21 ± 8 | 0.64 ± 0.02 | 0.93 ± 0.05* | 49 ± 11 |
| Systolic Function Parameters | ||||||
| EF, % | 46 ± 2 | 55 ± 3* | 23 ± 7 | 44 ± 1 | 63 ± 3* | 45 ± 8 |
| Diastolic Function Parameters | ||||||
| E-Peak V, cm/s | 72 ± 1 | 82 ± 5 | 13 ± 6 | 66 ± 2 | 74 ± 2 | 14 ± 5 |
| IVRT / R-R, ×100 | 13.5 ± 0.4 | 13.6 ± 1.0 | 4 ± 10 | 13.4 ± 0.4 | 12.2 ± 0.7 | -9 ± 6 |
P< 0.05 versus pre group (same genetic background) (one-way ANOVA, Tukey-Kramer post hoc)