. Author manuscript; available in PMC: 2011 Sep 1.

Published in final edited form as: Clin Immunol. 2010 May 15;136(3):400–408. doi: 10.1016/j.clim.2010.04.016

Table 2. In vitro naïve T cell proliferation correlates with magnitude of response to immunization with neoantigen, but not prevalent antigen.

The table represents the correlation matrix between in vitro T cell proliferation and response to immunization; data are Spearman’s correlation coefficients (P value). Note lack of correlation with response to TT (a recall antigen), but significant correlations with DTH and antibody response to KLH (a neoantigen).

In vitro T cell proliferation	Response to KLH immunization			Response to TT immunization
In vitro T cell proliferation	LPA^a	DTH^b	ABt^c	LPA^a	DTH^b	ABt^c
Vβ3+ CD4+^d	0.167 (NS)	0.334 (NS)	0.373 (0.04)	0.229 (NS)	−0.087 (NS)	−0.102 (NS)
Vβ5+ CD4+^d	0.236 (NS)	0.387 (0.04)	0.371 (0.05)	0.243 (NS)	−0.098 (NS)	0.064 (NS)
Vβ3+ CD8+^d	0.312 (NS)	0.401 (0.03)	0.279 (NS)	0.195 (NS)	0.014 (NS)	0.275 (NS)
Vβ5+ CD8+^d	0.152 (NS)	0.305 (NS)	0.336 (NS)	0.124 (NS)	−0.109 (NS)	0.089 (NS)

LPA, lymphoproliferative assay; DTH, delayed-type hypersensitivity; ABt, antibody titer.

As stimulation index

As mm of induration at maximum diameter

As U/mL

As % of Vβ3 or Vβ5+ cells that expand after stimulation with the corresponding agonistic antibody