Table 1.
Frequencies of risk alleles and associations with prostate cancer risk in the MEC.
| OR(95% CI)a Risk Allele Frequency |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Chr. Gene | Allele Tested | African Americans 860 ca/575 co |
European Americans 468 ca/419 co |
Latinos 603 ca/572 co |
Japanese Americans 725 ca/684 co |
Native Hawaiians 112 ca/109 co |
Pooled 2768 ca/2,359 co |
P value | Phetb |
| rs721048 | 2p15 EHBP1 |
A | 0.86(0.59–1.26) 0.05 |
0.87(0.67–1.12) 0.19 |
1.49(1.19–1.87) 0.14 |
1.05(0.71–1.56) 0.04 |
0.52(0.24–1.12) 0.09 |
1.08(0.94–1.25) 0.09 |
0.26 | 3.9×10−3 |
| rs2660753 | 3p12.1 | T | 0.97(0.83–1.14) 0.46 |
1.06(0.81–1.39) 0.13 |
1.15(0.94–1.40) 0.20 |
1.30(1.09–1.55) 0.24 |
0.94(0.56–1.57) 0.18 |
1.11(1.01–1.21) 0.26 |
0.034 | 0.16 |
| rs9364554 | 6q25.3 SLC22A3 |
T | 1.10(0.82–1.48) 0.07 |
1.06(0.86–1.30) 0.27 |
1.15(0.95–1.39) 0.21 |
1.09(0.93–1.29) 0.34 |
1.07(0.69–1.68) 0.22 |
1.10(1.00–1.21) 0.22 |
0.062 | 0.99 |
| rs10486567 | 7p15.2 JAZF1 |
G | 1.18(1.00–1.40) 0.70 |
1.50(1.19–1.89) 0.74 |
1.19(1.00–1.40) 0.53 |
1.14(0.88–1.48) 0.09 |
1.25(0.83–1.89) 0.36 |
1.23(1.12–1.35) 0.47 |
2.1×10−5 | 0.48 |
| rs6465657 | 7q21.3 LMTK2 |
C | 0.91(0.72–1.14) 0.85 |
1.08(0.89–1.31) 0.45 |
0.94(0.78–1.12) 0.70 |
1.04(0.82–1.33) 0.90 |
0.98(0.65–1.49) 0.67 |
0.99(0.89–1.09) 0.75 |
0.80 | 0.77 |
| rs10993994 | 10q11.23 MSMB |
T | 1.05(0.90–1.24) 0.59 |
1.15(0.96–1.39) 0.42 |
1.06(0.90–1.25) 0.37 |
1.26(1.08–1.46) 0.45 |
1.10(0.75–1.61) 0.64 |
1.13(1.04–1.23) 0.47 |
3.1×10−3 | 0.52 |
| rs12769019 | 10q26.13 CTBP2 |
G | 1.20(0.98–1.47) 0.16 |
1.12(0.90–1.39) 0.26 |
1.00(0.83–1.21) 0.24 |
1.43(0.75–2.76) 0.01 |
1.42 (0.68–2.95) 0.07 |
1.11(0.99–1.25) 0.15 |
0.062 | 0.60 |
| rs7931342 | 11q13.2 | G | 1.12(0.93–1.35) 0.76 |
1.28(1.05–1.55) 0.51 |
1.27(1.07–1.51) 0.37 |
0.87(0.73–1.05) 0.23 |
1.19(0.79–1.80) 0.48 |
1.13(1.03–1.23) 0.45 |
8.4×10−3 | 0.023 |
| rs11649743 | 17q12 HNF1B |
G | 1.04(0.79–1.38) 0.91 |
1.05(0.82–1.35) 0.82 |
1.29(1.04–1.61) 0.82 |
1.08(0.91–1.27) 0.70 |
0.96(0.65–1.41) 0.62 |
1.10(0.99–1.22) 0.80 |
0.067 | 0.58 |
| rs4430796 | 17q12 HNF1B |
A | 0.99(0.84–1.16) 0.35 |
1.44(1.18–1.74) 0.48 |
1.26(1.07–1.50) 0.57 |
1.04(0.89–1.22) 0.64 |
1.23(0.79–1.90) 0.70 |
1.15(1.06–1.25) 0.53 |
9.1×10−4 | 0.026 |
| rs1859962 | 17q24.3 | G | 1.01(0.86–1.19) 0.32 |
1.00(0.83–1.20) 0.51 |
1.10(0.93–1.30) 0.60 |
1.06(0.89–1.25) 0.26 |
1.03(0.69–1.52) 0.56 |
1.04(0.96–1.13) 0.42 |
0.35 | 0.95 |
| rs2735839 | 19q13 KLK2/3 |
G | 0.80(0.67–0.95) 0.71 |
1.33(1.02–1.75) 0.84 |
1.15(0.94–1.40) 0.77 |
1.21(1.03–1.41) 0.58 |
0.91(0.61–1.35) 0.51 |
1.06(0.97–1.16) 0.70 |
0.20 | 2.0×10−3 |
| rs5945572 | Xp11.22 NUDT10/11 |
A | 1.34(1.05–1.71) 0.26 |
1.25(0.95–1.66) 0.35 |
1.32(0.98–1.77) 0.17 |
1.25(0.86–1.82) 0.08 |
1.65(0.61–4.46) 0.06 |
1.31(1.13–1.51) 0.19 |
2.6×10−4 | 0.98 |
a
ORs adjusted for age (quintiles), genome-wide European ancestry (African Americans, Latinos and Native Hawaiians) and age-ethnicity strata (pooled analysis).
b
Phet = p value for heterogeneity of allelic effects across ethnic groups (4 df test)