Table 2.
OR(95% CI)a Risk Allele Frequency |
OR(95% CI)a Risk Allele Frequency |
||||
---|---|---|---|---|---|
SNP | Chr. Gene | Allele Tested | Advanced Cases 961 ca/2359 co |
Non-Advanced Cases 1600 ca/2359 co |
Phetb |
rs721048 | 2p15 EHBP1 |
A | 1.00(0.82–1.21) 0.09 |
1.11(0.94–1.30) 0.09 |
0.33 |
rs2660753 | 3p12.1 | T | 1.15(1.01–1.30) 0.26 |
1.06(0.96–1.19) 0.26 |
0.26 |
rs9364554 | 6q25.3 SLC22A3 |
T | 1.06(0.93–1.21) 0.22 |
1.12(0.99–1.25) 0.22 |
0.53 |
rs10486567 | 7p15.2 JAZF1 |
G | 1.13(0.99–1.29) 0.47 |
1.31(1.17–1.46) 0.47 |
0.088 |
rs6465657 | 7q21.3 LMTK2 |
C | 0.95(0.83–1.08) 0.75 |
1.04(0.93–1.17) 0.75 |
0.17 |
rs10993994 | 10q11.23 MSMB |
T | 1.07(0.96–1.20) 0.47 |
1.16(1.06–1.27) 0.47 |
0.19 |
rs12769019 | 10q26.13 CTBP2 |
G | 1.16(1.00–1.36) 0.15 |
1.08(0.94–1.23) 0.15 |
0.36 |
rs7931342 | 11q13.2 | G | 1.17(1.04–1.32) 0.45 |
1.10(1.00–1.22) 0.45 |
0.37 |
rs11649743 | 17q12 HNF1B |
G | 1.14(0.99–1.32) 0.80 |
1.10(0.98–1.25) 0.80 |
0.69 |
rs4430796 | 17q12 HNF1B |
A | 1.16(1.03–1.30) 0.53 |
1.15(1.05–1.27) 0.53 |
0.88 |
rs1859962 | 17q24.3 | G | 1.00(0.89–1.12) 0.42 |
1.07(0.97–1.18) 0.42 |
0.27 |
rs2735839 | 19q13 KLK2/3 |
G | 1.03(0.91–1.17) 0.70 |
1.09(0.98–1.21) 0.70 |
0.33 |
rs5945572 | Xp11.22 NUDT10/11 |
A | 1.27(1.04–1.55) 0.19 |
1.31(1.11–1.54) 0.19 |
0.84 |
ORs adjusted for age(quintiles)-ethnicity strata, and genome-wide European ancestry (African Americans, Latinos and Native Hawaiians)
Phet = p value for heterogeneity (advanced vs. non-advanced)