Table 3.
Relative potency ratios (A:Ba), ECx and slope dose-additivity quotient (AQ) and ECx independence quotient (IQ) values for three halogenated acetonitrile mixtures tested in Microtox®
| Mixture | Time (min) | A:B | AQ–EC25 | AQ–EC50 | AQ–EC75 | AQ-slope | IQ–EC25 | IQ–EC50 | IQ–EC75 |
|---|---|---|---|---|---|---|---|---|---|
| IAN–BRANb | 15 | 1:1.22 | 1.01 | 1.01 | 1.00 | 1.01 | 0.84 | 0.90 | 1.04 |
| 30 | 1:1.24 | 1.03 | 1.03 | 1.03 | 1.00 | 0.83 | 0.89 | 1.02 | |
| 45 | 1:1.32 | 1.04 | 1.03 | 1.02 | 1.02 | 0.83 | 0.87 | 0.98 | |
| IAN–CLAN | 15 | 1:0.91 | 0.97 | 0.97 | 0.97 | 1.00 | 0.81 | 0.87 | 1.00 |
| 30 | 1:0.96 | 0.99 | 0.98 | 0.97 | 1.01 | 0.79 | 0.84 | 0.95 | |
| 45 | 1:1.01 | 1.01 | 0.99 | 0.99 | 1.02 | 0.79 | 0.83 | 0.94 | |
| BRAN–CLAN | 15 | 1:0.86 | 1.09 | 1.05 | 1.02 | 1.05 | 0.91 | 0.95 | 1.06 |
| 30 | 1:0.87 | 1.09 | 1.06 | 1.04 | 1.04 | 0.87 | 0.91 | 1.02 | |
| 45 | 1:0.87 | 1.11 | 1.08 | 1.06 | 1.03 | 0.88 | 0.92 | 1.03 |
a
Relative potency ratio of the first agent (A) to the second agent (B) in the mixture
b
IAN iodoacetonitrile, BRAN bromoacetonitrile, CLAN chloroacetonitrile, 3M2B 3-methyl-2-butanone